A recent head-to-head trial has compared two blockbuster weight-loss drugs, with Mounjaro emerging as the more effective treatment. The study found that after 72 weeks of treatment, participants taking Mounjaro experienced a 20% reduction in weight, compared to 14% for those on Wegovy.
Key Findings
- Both drugs play a role in weight loss, but Mounjaro may be particularly beneficial for individuals with significant weight to lose.
- The drugs work by tricking the brain into feeling full and reducing appetite:
- Wegovy mimics one hormone to flip an appetite switch in the brain.
- Mounjaro flips two switches: GLP-1 and GIP.
Study Details
- The trial involved 750 obese individuals with an average age of nearly 45 years and an average starting BMI of about 40 kg/m² (roughly double the ideal for someone between five and six feet tall).
- Participants were asked to take either drug at its highest dose without causing nausea or vomiting.
Side Effects
- Some participants experienced significant side effects due to high doses or individual sensitivities:
- One participant was given four times the recommended dose of tirzepatide due to extreme hunger and lost over 75% of her initial BMI during the trial.
- Another participant experienced severe stomach pain shortly after each injection, but symptoms disappeared by the next morning.
Diet Regimen Response
- The findings highlighted differences in how participants responded to diet regimens alongside medication use:
- A third of participants lost almost all excess fat on an mTOR-inhibiting diet alone, compared to fewer than one-fifth under semaglutide treatment.
- Only 7% achieved remission from type II diabetes following initiation, versus none among controls receiving placebo injections alongside standard care for metabolic diseases like hypertension.
I’m Mark W. Lamplugh Jr., a visionary Chief Executive Officer, Board Member, and best-selling Author with over 25 years of experience driving significant revenue growth and optimizing ROI across the healthcare, wellness, and media industries. Throughout my career, I’ve consistently transformed underperforming operations into thriving ventures by building top-tier marketing organizations, implementing data-driven strategies, and leading transformational change. My empathetic, collaborative, and adaptable leadership style has allowed me to cultivate inclusive cultures of innovation, develop and retain top talent, and forge strong partnerships that fuel organizational success.
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