In a growing trend, people are turning to a unique facial treatment that involves microinjecting fragments of DNA or RNA derived from salmon sperm cells into the skin. This treatment, known as polynucleotide therapy, has been shown to have regenerative properties and is being hailed as a non-invasive way to rejuvenate the skin.
How Polynucleotide Therapy Works
The idea behind polynucleotide therapy is simple: by injecting fragments of DNA or RNA into the skin, it can stimulate collagen production and improve skin elasticity. According to a 2022 review published in the Chinese Journal of Plastic and Reconstructive Surgery, polynucleotides extracted from salmon sperm cells have been found to:
- Reduce fine lines and wrinkles
- Improve skin elasticity and firmness by enhancing collagen formation
Polynucleotides are essentially small pieces of genetic material that contain instructions for cell growth and repair. When injected into the skin, they can stimulate fibroblasts—cells responsible for producing collagen—to produce more collagen. This leads to improved skin texture and reduced signs of aging.
Benefits of Polynucleotide Therapy
Polynucleotides have also been shown to repair damage caused by chronic inflammation or prolonged sun exposure. According to Dr. Lee Seung-yeon, an aesthetic medicine specialist at Seoul National University Hospital in South Korea, "Polypeptide injections are not only effective against wrinkles but also against scars." He added that they "can be used on various parts of your body."
Research Findings
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Facial Scars Study:
- Conducted by researchers at Seoul National University Hospital.
- Examined 20 patients with facial scars caused by acne or surgery.
- Patients underwent Rejuran injections (a type of polynucleotide therapy) every two weeks for six months.
- Results showed noticeable improvements in all cases studied.
-
Burns Study:
- Conducted by researchers at Yonsei University College of Medicine’s Severance Medical Research Center.
- Used mice models with burn wounds treated with either saline solution alone or combined with Rejuran injection once per week for four weeks.
- Results showed significant improvement in the group receiving Rejuran compared to those receiving only saline solution.
Conclusion
While more research is needed to fully understand the potential benefits and risks associated with this new approach to treating various types of injuries, including burns and scarring, early evidence suggests a promising future ahead. This is especially notable considering the lack of invasive procedures required, unlike traditional methods that often come with hefty price tags and lengthy recovery times.

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